Accès ouvert

Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis protocol

Article scientifique 2020 Anglais

Résumé

Abstract Background: Cameroon remains a country faced with high malaria burden despite enormous efforts made in the control of the disease. The rapid development and dispersal of mutations associated with anti-malarial drug resistance influenced policy changes from the use of chloroquine, amodiaquine and sulphadoxine-pyrimethamine to the adoption of artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated falciparum malaria. However, the impact of drug policy changes on the evolution of molecular markers of Plasmodium falciparum resistance in Cameroon has not been completely understood. Hence, this systematic review and meta-analysis aims to determine the prevalence and distribution of P. falciparum drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon from 1998 to present.Methods: The PRISMA, PRISMA-P and STREGA statements will be adopted in the quality assessments of studies to be included in this review. The electronic databases of Medline via Pubmed, EMBASE, Google Scholar and Science Direct will be searched by two independent researchers using different MeSH terms and Boolean operators (AND, OR). More so, unpublished data that will be sourced from academic libraries will also be extracted. Quantitative syntheses will be done using the “metaphor” and “meta” commands in the R statistical software package version 3.5.2. Heterogeneity will be assessed using the Cochran’s Q and I2 statistics. The random effects model will be used as standard in the determination of heterogeneity between studies. Discussion: The primary outcome of this review is to identify and describe molecular markers conferring drug resistance in Plasmodium falciparum parasites that have been circulating for a period of over 20 years in Cameroon. This review will be able to pool data from previously published and unpublished studies on anti-malarial drug resistance gene mutations. This will provide evidence to support the continuous use of ACTs in the treatment of uncomplicated P. falciparum malaria. Furthermore, data generated from the study will be used as baseline information for the design and adoption of a robust anti-malarial drug resistance surveillance system nationwide which is inexistent. Systematic review registration: PROSPERO CRD42020162620

Citer ce document

Niba, P., Nji, A., Evehe, M., Ali, I., Netongo, P., Ngwafor, R., Moyeh, M., Ngum, L., Ndum, O., Acho, F., Mbu’u, C., Fosah, D., Atogho‐Tiedeu, B., Achonduh-Atijegbe, O., Djokam-Dadjeu, R., Bigoga, J., Moukoko, C., Ajua, A., Achidi, E., Tallah, E., Leke, R., Tourgordi, A., Ringwald, P., Alifrangis, M., Mbacham, W. (2020). Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis protocol. https://doi.org/10.21203/rs.3.rs-26096/v4

Accès au document

Voir sur le dépôt source

Ce document est hébergé sur son dépôt institutionnel d'origine.

Auteur(s)

Peter Thelma Ngwa Niba Akindeh M. Nji Marie‐Solange Evehe Innocent Mbulli Ali Palmer Masumbe Netongo Randolph Ngwafor Marcel N. Moyeh Lesley Ngum Ngum Oliva Ebie Ndum Fon Abongwa Acho Cyrille Mbanwi Mbu’u Dorothy A. Fosah Barbara Atogho‐Tiedeu Olivia Achonduh-Atijegbe Rosine Djokam-Dadjeu Jude D. Bigoga Carole Else Eboumbou Moukoko Anthony Ajua Eric Achidi Esther Tallah Rose G. F. Leke Alexis Tourgordi Pascal Ringwald Michael Alifrangis Wilfred Fon Mbacham

Statistiques

Consultations : 1

Téléchargements : 0