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Lessons from a comparison of immuno-chromatographic and chemiluminescent micro-particle immunoassay in the diagnosis of syphilis

Article scientifique 2018 Anglais

Résumé

OBJECTIVE: To synthesize lessons from comparison of results obtained from the immuno-chromatographic SD Bioline testing method and the chemiluminescent micro-particle immunoassay Architect in the diagnosis of syphilis at Livingstone Central hospital laboratory. RESULTS: The specificity and sensitivity of SD Bioline syphilis 3.0 against the chemiluminescent immunoassay using the Architect syphilis Treponema pallidum (TP) was 85.3% and 91.3% respectively with substantial agreement between the two test methods (88%, ĸ = 0.76; p < 0.0005). We recommend further comprehensive study with a larger sample size and clinical details to ascertain the validity of our findings. We also recommend using a non-treponemal test with the current treponemal tests being used to aid diagnosis.

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Masenga, S., Mweemba, M., Kachele, A., Chalubemba, Y., Toloka, P., Hamooya, B. (2018). Lessons from a comparison of immuno-chromatographic and chemiluminescent micro-particle immunoassay in the diagnosis of syphilis. https://doi.org/10.1186/s13104-018-3808-5

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Auteur(s)

Sepiso K. Masenga Mercy Mweemba Annie Kachele Yahns Chalubemba Paul Toloka Benson M. Hamooya

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