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Evaluation of the effect of topical calcipotriol versus platelet-rich plasma versus a combination of both on patients with Alopecia Areata

Article scientifique 2023 Anglais

Résumé

Abstract Background: Alopecia areata (AA) is considered to be an autoimmune disease that has different treatment modalities. Topical vitamin D analog and PRP are recognized as effective therapies for AA. The aim of the study was a compare the effect of topical vitamin D analog (calcipotriol), intra-lesion PRP, and a combination of both on AA patients. Patients and methods: In this double-blinded randomized clinical trial study, a total of 39 cases (patients with AA) were divided into 3 groups: Group I (n = 13): cases received topical Vit D3 analog (calcipotriol) 0.005% twice daily for 3 months with follow up. Group II (n = 13): cases received PRP intra-lesion injection for 6 consecutive sessions 2 weeks apart. Combined Group III (n = 13):cases received both treatments. Clinical evaluation by SALT score (severity alopecia tool) and dermoscopic examination were performed before and after treatment. Study registration at clinicaltrial.com was done, approval number: NCT05954104. Date of registration: 23/6/2023. Results: In this study, there was a significant decrease in the mean SALT score for the three groups (p<0.001). The absolute reduction in G-I (calcipotriol) was 3.73 points, in G-II (PRP), was 6.87 points, and in G-III(combined) was 18.98 points This reduction was significant (p<0.001) more evident in G-III followed by G-II and then G-I. There was a significant reduction in Dermoscopic findings after treatment in the three groups. Conclusion: Significant reductions in SALT levels were observed across all three groups, with the combination of calcipotriol and PRP being particularly noteworthy. Significant reductions in dermoscopic symptoms were observed following treatment.

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Ali, M., Taieb, M., Younis, A., Ibrahim, H., Abdellatif, M., Ahmed, N., Ahmed, F., Hegazy, E. (2023). Evaluation of the effect of topical calcipotriol versus platelet-rich plasma versus a combination of both on patients with Alopecia Areata. https://doi.org/10.21203/rs.3.rs-3600292/v1

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Auteur(s)

Mahmoud Ali Moustafa A. El Taieb Ali Younis Hassan Ibrahim Mohamed Amer Ahmed Abdellatif Nour Ahmed Faten Othman Ahmed Ahmed Eisa M. Hegazy

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