Accès ouvert

Metagenomic surveillance uncovers diverse and novel viral taxa in febrile patients from Nigeria

Article scientifique 2023 Anglais

Résumé

Effective infectious disease surveillance in high-risk regions is critical for clinical care and pandemic preemption; however, few clinical diagnostics are available for the wide range of potential human pathogens. Here, we conduct unbiased metagenomic sequencing of 593 samples from febrile Nigerian patients collected in three settings: i) population-level surveillance of individuals presenting with symptoms consistent with Lassa Fever (LF); ii) real-time investigations of outbreaks with suspected infectious etiologies; and iii) undiagnosed clinically challenging cases. We identify 13 distinct viruses, including the second and third documented cases of human blood-associated dicistrovirus, and a highly divergent, unclassified dicistrovirus that we name human blood-associated dicistrovirus 2. We show that pegivirus C is a common co-infection in individuals with LF and is associated with lower Lassa viral loads and favorable outcomes. We help uncover the causes of three outbreaks as yellow fever virus, monkeypox virus, and a noninfectious cause, the latter ultimately determined to be pesticide poisoning. We demonstrate that a local, Nigerian-driven metagenomics response to complex public health scenarios generates accurate, real-time differential diagnoses, yielding insights that inform policy.

Citer ce document

Oguzie, J., Petros, B., Oluniyi, P., Mehta, S., Eromon, P., Nair, P., Adewale-Fasoro, O., Ifoga, P., Odia, I., Pastusiak, A., Gbemisola, O., Aiyepada, J., Uyigue, E., Edamhande, A., Blessing, O., Airende, M., Tomkins-Tinch, C., Qu, J., Stenson, L., Schaffner, S., Oyejide, N., Ajayi, N., Ojide, K., Ogah, O., Abejegah, C., Adedosu, N., Ayodeji, O., Liasu, A., Okogbenin, S., Okokhere, P., Park, D., Folarin, O., Komolafe, I., Ihekweazu, C., Frost, S., Jackson, E., Siddle, K., Sabeti, P., Happi, C. (2023). Metagenomic surveillance uncovers diverse and novel viral taxa in febrile patients from Nigeria. https://doi.org/10.1038/s41467-023-40247-4

Accès au document

Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter

Voir l'article sur le site de la revue

Auteur(s)

Judith U. Oguzie Brittany A. Petros Paul E. Oluniyi Samar Mehta Philomena Eromon Parvathy Nair Opeoluwa Adewale-Fasoro Peace Damilola Ifoga Ikponmwosa Odia Andrzej Pastusiak Otitoola Shobi Gbemisola John Aiyepada Eghosasere Anthonia Uyigue Akhilomen Patience Edamhande Osiemi Blessing Michael Airende Christopher H. Tomkins-Tinch James Zhengzhong Qu Liam Stenson S. F. Schaffner Nicholas Oyejide Nnenna A. Ajayi Kingsley Chiedozie Ojide Onwe Emeka Ogah Chukwuyem Abejegah Nelson Adedosu Oluwafemi Ayodeji Ahmed A. Liasu Sylvanus Okogbenin Peter O. Okokhere Daniel J. Park Onikepe Folarin Isaac Komolafe Chikwe Ihekweazu Simon D. W. Frost Ethan K. Jackson Katherine J. Siddle Pardis C. Sabeti Christian Happi

Statistiques

Consultations : 1

Téléchargements : 0