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The file contains data on socio-demographics (age, parity, residence and gestational age), obstetric and medical history, bed net use, maternal weight, height and BMI, maternal hemoglobin, infant birth weights and maternal and umbilical cord leptin and IGF-1 levels for each participant.

Article scientifique 2025 Anglais

Résumé

Background: There are few published data on the association between leptin, insulin like growth factor-1 (IGF-1) and malaria during pregnancy. This study aimed to investigate maternal and umbilical cord leptin and IGF-1 levels and malaria during pregnancy, and their association - if any - with birth weight. Methods: A cross-sectional study was conducted at Medani, Sudan. Medical and obstetrics history was gathered from each parturient woman (n=175) and malaria was investigated by blood film and placental histology. Maternal and umbilical cord leptin and IGF-1 levels were measured using ELISA. Results: Upon histological examination, 48 women were infected with placental malaria, and 127 were found free from the disease. Out of the 48, 2 of the patients showed signs of active infection, 3 of chronic infection and 43 of previous infection. Placental malaria and preterm delivery were associated with low birth weight (< 2500 g). Younger mothers and primigravidae had a higher risk for placental malaria infection. There was no significant difference in maternal and umbilical cord leptin and IGF-1 levels between women infected with placental malaria and those free from the disease. Conclusions: The current study showed that low birth weight was significantly associated with placental malaria. Young mothers and primigravidae had a higher risk to develop the infection. There was no significant difference in the levels of maternal and umbilical cord leptin and IGF-1 levels between women infected with placental malaria and those free from the disease. Both the levels of maternal and cord leptin and IGF-1were found not to be associated with birth weight. Abbreviations: IGF-1: Insulin like growth factor-1; LBW: Low birth weight; ELISA: Enzyme-linked immunosorbent assay; PM: Placental malaria.

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Elsheikh, H., Adam, I., Elhassan, E., Mohammed, A., Khamis, A., Elbashir, M. (2025). The file contains data on socio-demographics (age, parity, residence and gestational age), obstetric and medical history, bed net use, maternal weight, height and BMI, maternal hemoglobin, infant birth weights and maternal and umbilical cord leptin and IGF-1 levels for each participant.. https://doi.org/10.5256/f1000research.10641.d158697

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Auteur(s)

Hagir Elsheikh Ishag Adam Elhassan M. Elhassan Ahmed A. Mohammed Ammar H. Khamis Mustafa I. Elbashir

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