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New anti-inflammatory guaianes from the Atlantic hydrotherm-derived fungus Graphostroma sp. MCCC 3A00421

Article scientifique 2018 Anglais

Résumé

Abstract Nine new guaianes (graphostromanes A–I, 1–9) were isolated from the deep-sea-derived fungus Graphostroma sp. MCCC 3A00421, along with four known ones (10–13). The relative configurations were established mainly by detailed analysis of the NMR and HRESIMS data, while the absolute configurations were assigned using the X-ray crystallography and modified Mosher’s method. All isolates were evaluated for their inhibitory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. Graphostromanes F (6) showed remarkable inhibitory effect with an IC50 value of 14.2 μM, which was even stronger than that of aminoguanidine, a positive control with an IC50 value of 23.4 μM.

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Niu, S., Xie, C., Xia, J., Luo, Z., Shao, Z., Yang, X. (2018). New anti-inflammatory guaianes from the Atlantic hydrotherm-derived fungus Graphostroma sp. MCCC 3A00421. https://doi.org/10.1038/s41598-017-18841-6

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Auteur(s)

Siwen Niu Chun‐Lan Xie Jin‐Mei Xia Zhu-Hua Luo Zongze Shao Xian‐Wen Yang

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