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Sociodemographic and Hematologic Profile of Breast Cancer Patients Attending a Tertiary Care Teaching Hospital in Ethiopia: Case Control Study

Article scientifique 2020 Anglais

Résumé

Abstract Background: Breast cancer is among the leading causes of cancer death in women. Different socio-demographic factors have impact on early diagnosis and treatment of breast cancer. Hematological abnormalities are also some of the conditions to be monitored during diagnosis and treatment of breast cancer.Objective: To describe socio demographic and hematologic profile of patients with breast cancer at Tikur Anbessa Specialized Hospital.Methods: Case control study was conducted from May 2018 to June 2019. A total of 230 cases and 230 controls participated in the study. Descriptive analysis was made to assess the socio demographic characteristics. Blood samples for hematological parameters were analyzed, using SYSMEXKX21N hematology analyzer. Independent student t- test was performed to compare the mean hematological parameters of cases and controls. Results: The mean age was 42.8 + 12.1 and 39.3 + 11.1 years for cases and controls, respectively. One hundred (43%) of cases and 34 (14.8%) of controls were illiterate. Moreover, 175 (76.1%) of cases and 155 (67.4%) of controls were married. The mean value of Hemoglobin, Red Blood cell, Packed Cell Volume (13.1 + 1.6g/dl, 4.6 + 0.54/1012/L , 38.7 + 4.5 %, respectively) of cases were significantly lower than the controls (14.0 + 1.3g/dl, 4.8 + 0.47 / 1012/L, 40.5 + 3.5% respectively). The mean platelet and total WBC count were 323.4+ 108.1 x 109/L and 7.1 + 2.8 x 109/L for cases and 282.0 +70.0 x 109/L, and 7.1 + 2.4 x 109/L for controls respectively. In addition, 20.4% of cases and 5.6 % of controls were anemic based on their hemoglobin value.Conclusion and recommendations: The majority of breast cancer cases were less than 40 years of age and illiterate. Most of the RBC parameters of cases were significantly lower than the controls. Therefore, attention should be given to those with the designated hematologic abnormalities.

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Dejene, F., Gashe, F., Ahmed, A., Nuramo, A., Aweke, G., Assefa, M., Abebe, A. (2020). Sociodemographic and Hematologic Profile of Breast Cancer Patients Attending a Tertiary Care Teaching Hospital in Ethiopia: Case Control Study. https://doi.org/10.21203/rs.3.rs-60844/v1

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Fatuma Hassen Dejene Fikre Enqusilassie Gashe Ahmed Ali Ahmed Adamu Addise Nuramo Girma Taye Aweke Mathewos Assefa A. Abebe

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