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Investigation of urinary metabolomics in a phase I hookworm vaccine trial in Gabon

Article scientifique 2022 Anglais

Résumé

Metabolomics provides a powerful tool to study physiological changes in response to various perturbations such as vaccination. We explored whether metabolomic changes could be seen after vaccination in a phase I trial where Gabonese adults living either in rural or semi-urban areas received the subunit hookworm vaccine candidates (Na-GST-1 and Na-APR-1 (M74) adjuvanted with Alhydrogel plus GLA-AF (n = 24) or the hepatitis B vaccine (n = 8) as control. Urine samples were collected and assayed using targeted 1H NMR spectroscopy. At baseline, a set of metabolites significantly distinguished rural from semi-urban individuals. The pre- and post-vaccination comparisons indicated significant changes in few metabolites but only one day after the first vaccination. There was no relationship with immunogenicity. In conclusion, in a small phase 1 trial, urinary metabolomics could distinguish volunteers with different environmental exposures and reflected the safety of the vaccines but did not show a relationship to immunogenicity.

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Ongwe, M., Mouwenda, Y., Stam, K., Kremsner, P., Lell, B., Diemert, D., Bethony, J., Bottazzi, M., Hotez, P., Leeuwen, R., Grobusch, M., Adégnika, A., Mayboroda, O., Yazdanbakhsh, M. (2022). Investigation of urinary metabolomics in a phase I hookworm vaccine trial in Gabon. https://doi.org/10.1371/journal.pone.0275013

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Auteur(s)

Madeleine Eunice Betouke Ongwe Yoanne D. Mouwenda Koen A. Stam Peter G. Kremsner Bertrand Lell David Diemert Jeff Bethony María Elena Bottazzi Peter J. Hotez Remko van Leeuwen Martin P. Grobusch Ayôla Akim Adégnika Oleg A. Mayboroda Maria Yazdanbakhsh

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