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Peer Review Report For: Assessment of sub-maximal aerobic capacity in North African patients with chronic hepatitis B: a pilot case-control study [version 2; peer review: 2 approved]

Article scientifique 2025 Anglais

Résumé

Background Studies assessing sub-maximal aerobic capacity in non-cirrhotic chronic hepatitis B (CHB) patients are scarce. This study aimed to evaluate sub-maximal aerobic capacity in CHB patients compared to apparently healthy participants (control-group (CG)). Methods A 6-min walk test (6MWT) was performed. The 6-min walk distance (6MWD) was recorded, along with heart-rate (HR), oxy-hemoglobin saturation (SpO 2 ), blood-pressure, and dyspnea ( ie ; visual analogue scale) at rest (Rest) and at the end (End) of the 6MWT. Additionally, the 6-min walk work (6MWW), and “estimated cardiorespiratory and muscular chain age” were calculated. Signs of physical intolerance were determined including abnormal 6MWD ( ie ; 6MWD < lower limit of normal), chronotropic insufficiency (ie ; HREnd < 60% of maximal predicted HR (MPHR)), high dyspnea ( ie ; dyspneaEnd > 5), and desaturation ( ie ; drop in SpO 2 > 5 points). Results Compared to the CG (n=28), the CHB-group (n=26) exhibited significantly lower 6MWD by 61 meters (8%), lower 6MWW by 10%, and lower HR End by 21% (when expressed in bpm) and 17% (when expressed in %MPHR). The CHB-group, compared to the CG, included higher percentages of participants with chronotropic insufficiency and abnormal 6MWD (23.08% vs. 3.57%, and 34.61% vs. 3.57%, respectively). The CHB-group was 8.1 and 14.3 times more likely to have chronotropic insufficiency and abnormal 6MWD than the CG, respectively. CHB accelerated the aging of the “cardiorespiratory and muscular chain” by 11 years. Conclusion Non-cirrhotic CHB may contribute to reduced submaximal aerobic capacity and acceleration of “cardiorespiratory and muscular chain” aging.

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Bergaoui, J., Latiri, I., Mrad, S., Chaouch, H., Amous, S., Abdallah, J., Hajri, S., Saad, H. (2025). Peer Review Report For: Assessment of sub-maximal aerobic capacity in North African patients with chronic hepatitis B: a pilot case-control study [version 2; peer review: 2 approved]. https://doi.org/10.5256/f1000research.179982.r376730

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Auteur(s)

Jihene Bergaoui Imed Latiri Sawssen Mrad Houda Chaouch Salma Amous Jihene Ben Abdallah Samia Ernez Hajri Helmi Ben Saad

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