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Tamarindus indica Ameliorates Neural Aluminum Chloride Toxicity in Neonatal Wistar rats

Article scientifique 2021 Anglais

Résumé

Abstract Objective:This was to determine levels of heavy metal expression following Tamarindus indica activity in neonatal rats. Pregnant timed rats were divided into 5 groups (n =4) and neonatal rats were used. Group 1 (negative control), Groups II-V were experimental groups treated with 100 mg/kg of AlCl3 s/c. Group II (positive control), Groups III and IV receiving 400mg/kg and 800mg/kg of Tamarindus indica respectively, and Group 5 receiving 30mg/kg of Vitamin E (comparative control) for 3 weeks. Brain metal; copper, zinc, iron, and calcium (Cu, Zn, Fe, and Ca respectively) quantification was done using atomic absorption spectrophotometer. Results:Tamarindus indica contained 61.6% Oleic Acid, n-Hexadecanoic acid 11.03%, Phenol, 3,5-bis (1,1-dimethyl ethyl)- 8.48 %, and cis-9-Hexadecenal 7.79% as the main components in Tamarindus indica. The differential expression of brain metals in the treatment groups on post gestation day 7 and 21 revealed significantly high mean Zn, Fe, and Cu and lower Ca expression in the positive control compared to the negative control; but significantly lower mean Zn, Fe, and Cu and higher Ca expression was observed in the group treated with 400 and 800mg/kg bw of EATI and comparative control when compared to values observed in positive control.

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Usman, I., Musa, S., Iliya, I., Aigbogun, E., Kasozi, K., Batiha, G., Adebisi, S. (2021). Tamarindus indica Ameliorates Neural Aluminum Chloride Toxicity in Neonatal Wistar rats. https://doi.org/10.21203/rs.3.rs-322260/v1

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Auteur(s)

Ibe Michael Usman Sunday Abraham Musa Ibrahim Abdullahi Iliya Eric Aigbogun Keneth Iceland Kasozi Gaber El‐Saber Batiha Samuel Sunday Adebisi

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