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Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men

Article scientifique 2023 Anglais

Résumé

The association between fatty acids and prostate cancer remains poorly explored in African-descent populations. Here, we analyze 24 circulating fatty acids in 2934 men, including 1431 prostate cancer cases and 1503 population controls from Ghana and the United States, using CLIA-certified mass spectrometry-based assays. We investigate their associations with population groups (Ghanaian, African American, European American men), lifestyle factors, the fatty acid desaturase (FADS) genetic locus, and prostate cancer. Blood levels of circulating fatty acids vary significantly between the three population groups, particularly trans, omega-3 and omega-6 fatty acids. FADS1/2 germline genetic variants and lifestyle factors explain some of the variation in fatty acid levels, with the FADS1/2 locus showing population-specific associations, suggesting differences in their control by germline genetic factors. All trans fatty acids, namely elaidic, palmitelaidic, and linoelaidic acids, associated with an increase in the odds of developing prostate cancer, independent of ancestry, geographic location, or potential confounders.

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Minas, T., Lord, B., Zhang, A., Candia, J., Dorsey, T., Baker, F., Tang, W., Bailey‐Whyte, M., Smith, C., Obadi, O., Ajao, A., Jordan, S., Tettey, Y., Biritwum, R., Adjei, A., Mensah, J., Hoover, R., Hsing, A., Liu, J., Loffredo, C., Yates, C., Cook, M., Ambs, S. (2023). Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men. https://doi.org/10.1038/s41467-023-39865-9

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Auteur(s)

Tsion Z. Minas Brittany D. Lord Amy L. Zhang Julián Candia Tiffany H. Dorsey Francine Baker Wei Tang Maeve Bailey‐Whyte Cheryl J. Smith Obadi M. Obadi Anuoluwapo Ajao Symone V. Jordan Yao Tettey Richard Biritwum Andrew A. Adjei James E. Mensah Robert N. Hoover Ann W. Hsing Jia Liu Christopher A. Loffredo Clayton Yates Michael B. Cook Stefan Ambs

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