Prediction of Postmenopausal Status in Premenopausal Early Stage Breast Cancer Patients after Adjuvant Chemotherapy

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\n\tIntroduction: Chemotherapy; a well-known modality for treatment of breast cancer, has an effect on ovarian functions as it can induce premature ovarian failure and chemotherapy induced amenorrhea (CIA). This CIA has an impact on treatment decision. \n \n\tAim of the study: Predict the postmenopausal status in premenopausal, early-stage breast cancer patients, after receiving adjuvant chemotherapy, to evaluate the possibility of using aromatase-inhibitors in those patients. \n \n\tMethods and Material: In this study the changes in serum levels of estradiol (E2) and follicular-stimulating hormone (FSH) was observed in 50 early breast cancer patients in Medical Research Institute at Alexandria, who developed CIA. The E2 and FSH levels in those patients was measured three times; once CIA was recorded, then after six month, then after one year, and correlated with menstrual history at each visit, and then the collected data were presented in tables and figures, with statistical analysis of these data. \n \n\tResults: The E2 levels decreased once CIA was recorded then it increased after 6 months and still increased after one year of follow-up, while the levels of FSH increased once the amenorrhea was recorded and it decreased after 6 months and one year of follow-up, the hormonal profile of patients who developed CIA was similar to that of patients who suffer from primary ovarian failure, and patients who had a serum E2 below 20pg/ml and/or FSH 40 IU/L or more once the CIA was recorded will not regain menses again after one year of follow-up. \n \n\tConclusion: Serum levels of estradiol (E2) and follicular-stimulating hormone (FSH) could be used to predict the postmenopausal status in premenopausal early stage breast cancer patients after receiving adjuvant chemotherapy.

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