Investigations of the antioxidants, antidiabetics and antiviral potential against SARS-CoV-2 of gold functionalized carboxymethyl cellulose

Résumé

Abstract A composite of gold and carboxymethyl cellulose (Au-CMC) was prepared from gold(III) chloride and the sodium salt of carboxymethyl cellulose. The prepared composite was characterized by using x-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and Energy-dispersive x-ray spectroscopy (EDX). Then, ferric reducing, nitric oxide scavenging and free radical scavenging activities of the synthesized Au-CMC were carried out. In addition, inhibitory activities of the material against α-amylase, α-glucosidase enzymes and SARS-CoV-2 were studied. It was found that the material displayed good antioxidant activities. Especially, its NO scavenging activities was higher than that of vanillin, gold nanoparticles and carboxymethyl cellulose alone. The α-glucosidase enzyme inhibitory effect of the material was better than that of acarbose. Findings also revealed that both CMC and Au-CMC are highly potent against B1.351 and BQ.1.1 variants of SARS-CoV-2. Finally, cytotoxicity studies showed that the two compounds can be used safely in biomedical applications, such as drug delivery, tissue engineering, or as stabilizers in formulations, without concerns.

Citer ce document

Accès au document

Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter

Auteur(s)

Statistiques

Consultations : 1

Téléchargements : 0