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The Human Cell Atlas

Article scientifique 2017 Anglais

Résumé

Abstract The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body, by undertaking a Human Cell Atlas Project as an international collaborative effort. The aim would be to define all human cell types in terms of distinctive molecular profiles (e.g., gene expression) and connect this information with classical cellular descriptions (e.g., location and morphology). A comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, as well as provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas.

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Regev, A., Teichmann, S., Lander, E., Amit, I., Benoıst, C., Birney, E., Bodenmiller, B., Campbell, P., Carninci, P., Clatworthy, M., Clevers, H., Deplancke, B., Dunham, I., Eberwine, J., Eils, R., Enard, W., Farmer, A., Fugger, L., Göttgens, B., Hacohen, N., Haniffa, M., Hemberg, M., Kim, S., Klenerman, P., Kriegstein, A., Lein, E., Linnarsson, S., Lundeberg, J., Majumder, P., Marioni, J., Mérad, M., Mhlanga, M., Nawijn, M., Netea, M., Nolan, G., Pe’er, D., Phillipakis, A., Ponting, C., Quake, S., Reik, W., Rozenblatt–Rosen, O., Sanes, J., Satija, R., Schumacher, T., Shalek, A., Shapiro, E., Sharma, P., Shin, J., Stegle, O., Stratton, M., Stubbington, M., Oudenaarden, A., Wagner, A., Watt, F., Weissman, J., Wold, B., Xavier, R., Yosef, N. (2017). The Human Cell Atlas. https://doi.org/10.1101/121202

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Auteur(s)

Aviv Regev Sarah A. Teichmann Eric S. Lander Ido Amit Christophe Benoıst Ewan Birney Bernd Bodenmiller Peter J. Campbell Piero Carninci Menna R. Clatworthy Hans Clevers Bart Deplancke Ian Dunham James Eberwine Roland Eils Wolfgang Enard Andrew Farmer Lars Fugger Berthold Göttgens Nir Hacohen Muzlifah Haniffa Martin Hemberg Seung K. Kim Paul Klenerman Arnold R. Kriegstein Ed S. Lein Sten Linnarsson Joakim Lundeberg Partha Majumder John C. Marioni Miriam Mérad Musa M. Mhlanga Martijn C. Nawijn Mihai G. Netea Garry P. Nolan Dana Pe’er Anthony Phillipakis Chris P. Ponting Steve Quake Wolf Reik Orit Rozenblatt–Rosen Joshua R. Sanes Rahul Satija Ton N. Schumacher Alex K. Shalek Ehud Shapiro Padmanee Sharma Jay W. Shin Oliver Stegle Michael Stratton Michael J. T. Stubbington Alexander van Oudenaarden Allon Wagner Fiona M. Watt Jonathan S. Weissman B Wold Ramnik J. Xavier Nir Yosef

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