EXTRACTION, PHYTOCHEMICAL CHARACTERIZATION AND IN-VIVO ANTIPYRETIC ACTIVITIES OF METHANOL EXTRACT OF CISSUS ARGUTA LEAVES

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The study focused on the extraction, characterization, and antipyretic activities of methanol extract from Cissus arguta leaves. The experimental procedures involved sample collection, preparation, and solvent extraction using methanol extract in a Soxhlet extractor. The extract was further characterized for its phytochemical constituents following standard procedure. Male and female albino rats were used for the studies, and brewer’s yeast-induced pyrexia was conducted the animal models prior to the antipyretic treatment with the extract. Phytochemical screening revealed cardiac glycosides, phenols, saponins, tannins, terpenoids and quinones. The antipyretic analysis showed that the plant is significantly effective. Compared to a dose of 150mg/kg paracetamol with a mean reduction of 1.258o, that of C. arguta leaves was 0.725o for 150 mg/kg, 1.217o for 300 mg/kg and 2.133o for 400 mg/kg. Our findings support the potential therapeutic use of C. arguta as a natural antipyretic agent, suitable for Integration into modern healthcare. This revealed alternative therapies, leveraging on the rich biodiversity of our natural environment.

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