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Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials

Article scientifique 2024 Anglais

Résumé

Ebola virus disease (EVD) is a filoviral infection caused by virus species of the Ebolavirus genus including Zaire ebolavirus (EBOV) and Sudan ebolavirus (SUDV). We investigated the safety and immunogenicity of a heterologous prime-boost regimen involving a chimpanzee adenovirus 3 vectored Ebola vaccine [either monovalent (cAd3-EBOZ) or bivalent (cAd3-EBO)] prime followed by a recombinant modified vaccinia virus Ankara EBOV vaccine (MVA-EbolaZ) boost in two phase 1/1b randomized open-label clinical trials in healthy adults in the United States (US) and Uganda (UG). Trial US (NCT02408913) enrolled 140 participants, including 26 EVD vaccine-naïve and 114 cAd3-Ebola-experienced participants (April-November 2015). Trial UG (NCT02354404) enrolled 90 participants, including 60 EVD vaccine-naïve and 30 DNA Ebola vaccine-experienced participants (February-April 2015). All tested vaccines and regimens were safe and well tolerated with no serious adverse events reported related to study products. Solicited local and systemic reactogenicity was mostly mild to moderate in severity. The heterologous prime-boost regimen was immunogenic, including induction of durable antibody responses which peaked as early as two weeks and persisted up to one year after each vaccination. Different prime-boost intervals impacted the magnitude of humoral and cellular immune responses. The results from these studies demonstrate promising implications for use of these vaccines in both prophylactic and outbreak settings.

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Happe, M., Hofstetter, A., Wang, J., Yamshchikov, G., Holman, L., Novik, L., Strom, L., Kiweewa, F., Wakabi, S., Millard, M., Kelley, C., Kabbani, S., Edupuganti, S., Beck, A., Kaltovich, F., Murray, T., Tsukerman, S., Carr, D., Ashman, C., Stanley, D., Ploquin, A., Bailer, R., Schwartz, R., Cham, F., Tindikahwa, A., Hu, Z., Gordon, I., Rouphael, N., Houser, K., Coates, E., Graham, B., Koup, R., Mascola, J., Sullivan, N., Robb, M., Ake, J., Lyke, K., Mulligan, M., Ledgerwood, J., Kibuuka, H., team, t., Casazza, J., Chen, G., Enama, M., Gaudinski, M., Hendel, C., Costner, P., Larkin, B., Mendoza, F., Sanders, J., Whalen, W., Zephir, K., Straling, J., DeCederfelt, H., Conan-Cibotti, M., Stein, J., Pittman, I., Vasilenko, O., DeZure, A., Sitar, S., Dropulic, L., Plummer, S., Nguyen, T., Berkowitz, N., Greenberg, N., Chrisley, L., Billington, M., Wang, X., Becker, J., Campbell, J., Chen, W., Kwon, A., Dorsey, B., Courneya, J., Komninou, P., Lee, M., Bower, M., Bailey, C., Nesheim, W., Girmay, T., Xu, J., Ogilvie, M., Sadowski, J., Osinski, E., Lai, L., Grimes, V., Kamya, M., Michael, N., Kajumba, F., Ananworanich, J., Mwesigwa, B., Kimbugne, G., Luzinda, K., Nakabuye, I., Mukyala, M., Kabahubya, M., Nakibuuka, L., Matovu, R. (2024). Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials. https://doi.org/10.1038/s41541-024-00833-z

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Auteur(s)

Myra Happe Amelia Ruth Hofstetter Jing Wang Galina V. Yamshchikov LaSonji A. Holman Laura Novik Larisa Strom Francis Kiweewa Salim Wakabi Monica Millard Colleen Frances Kelley Sarah Kabbani Srilatha Edupuganti Allison Beck Florence A. Kaltovich Tamar Murray Susanna Tsukerman Derick Carr Carl Ashman Daphne A. Stanley Aurélie Ploquin Robert T. Bailer Richard M. Schwartz Fatim Cham Allan Tindikahwa Zonghui Hu Ingelise J. Gordon Nadine Rouphael Katherine V. Houser Emily E. Coates Barney S. Graham Richard A. Koup John R. Mascola Nancy J. Sullivan Merlin L. Robb Julie A. Ake Kirsten E. Lyke Mark J. Mulligan Julie E. Ledgerwood Hannah Kibuuka the VRC 208 and RV 422 study team Joseph Paul Casazza Grace L. Chen Mary E. Enama Martin Robert Gaudinski Cynthia Starr Hendel Pamela J. M. Costner Brenda D. Larkin Floreliz H. Mendoza Jamie Sanders William R. Whalen Kathryn L. Zephir Judith Straling Hope DeCederfelt Michelle Conan-Cibotti Judy Stein Iris Pittman Olga Vasilenko Adam D. DeZure Sandra Sitar Lesia K. Dropulic Sarah H. Plummer Thuy A. Nguyen Nina M. Berkowitz Nancy Greenberg Lisa Chrisley Melissa Billington Xiaolin Wang Jo Anna L. Becker James D. Campbell Wilbur H. Chen Alyson Kwon Brenda Dorsey Jennifer Courneya Panagiota Komninou Myounghee Lee Mary Bower Charles A. Bailey Wendy Nesheim Tigisty Girmay Jianguo Xu Melinda Ogilvie Joann Sadowski Eileen Osinski Lilin Lai Vicki Grimes Moses R. Kamya Nelson L. Michael Francis Kajumba Jinantat Ananworanich Betty Mwesigwa Geofrey Kimbugne Kenneth Luzinda Immaculate Nakabuye Maureen G. Mukyala Mable Kabahubya Lydia Nakibuuka Robinah Matovu

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