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Evidence for familial aggregation in siblings with autoimmune rheumatic diseases

Article scientifique 2018 Anglais

Résumé

Autoimmune rheumatic disorders have a multifactorial determinism, caused by various environmental factors acting on the individual's genetic susceptibility, destabilizing the systems which regulate the immune response. Epidemiological and genetic investigations are very important to demonstrate the contribution of genetic factors to the development of these autoimmune diseases. The contribution of genetic factors in causing autoimmune diseases has been demonstrated by familial aggregation. Moreover, it was also quantified by determining heritability, expressing the proportion of genetic factors in the etiology. It is now clear that common genes underlie multiple autoimmune disorders.

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Dună, M., Predețeanu, D., Berghea, F., Abobului, M., Vlad, V., Bălănescu, A., Opriș-Belinski, D., Bojincă, V., Constantinescu, C., Borangiu, A., Groşeanu, L., Săulescu, I., Negru, M., Cobilinschi, C., Daia, S., Mazilu, D., Ionescu, R. (2018). Evidence for familial aggregation in siblings with autoimmune rheumatic diseases. https://doi.org/10.37897/rjr.2018.1.3

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Auteur(s)

Mădălina-Puşa Dună Denisa Predețeanu Florian Berghea M. Abobului Violeta Vlad Andra Bălănescu Daniela Opriș-Belinski Violeta Bojincă C Constantinescu A. Borangiu L. Groşeanu I. Săulescu Maria-Magdalena Negru Claudia Cobilinschi Sânziana Daia Diana Mazilu Ruxandra Ionescu

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