Efficacy of acetylsalicylic acid in schizophrenia: a literature review

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Introduction There has been growing evidence to support the hypothesis that inflammation is involved in the pathogenesis of schizophrenia. Objectives The aim of the present literature review was to assess the efficacy of acetylsalicylic acid (ASA) as an adjuvant agent in the treatment of an acute exacerbation of schizophrenia. Methods We searched randomized clinical trials based on regular searches of MEDLINE, Embase, PubMed. Results We included four studies. The results were in favor of the efficacy of ASA in the study where authors targeted early psychosis. Illness duration seems to predict response to anti-inflammatory agents. Conclusions Further studies of early stages of schizophrenia are helpful. Disclosure of Interest None Declared

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