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Clinico-pathological relationship between androgen receptor and tumour infiltrating lymphocytes in triple negative breast cancer

Article scientifique 2021 Anglais

Résumé

BACKGROUND: Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer (BC) with ill-defined therapeutic targets. Androgen receptor (AR) and tumour-infiltrating lymphocytes (TILs) had a prognostic and predictive value in TNBC. The relationship between AR, TILs and clinical behaviour is still not fully understood. METHODS: Thirty-six TNBC patients were evaluated for AR (positive if ≥1% expression), CD3, CD4, CD8 and CD20 by immunohistochemistry. Stromal TILs were quantified following TILs Working Group recommendations. Lymphocyte-predominant breast cancer (LPBC) was defined as stromal TILs ≥ 50%, whereas lymphocyte-deficient breast cancer (LDBC) was defined as <50%. RESULTS: = 0.04). CONCLUSIONS: AR expression was evident in older age (≥50 years). Median CD20 was higher in AR- TNBC, while mean CD3 was higher in AR+ tumours. LDBC was associated with higher risk of LN involvement. Larger studies are needed to focus on the clinical impact of the relation between AR and TILs in TNBC.

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Elghazawy, H., Bakkach, J., Helal, T., Aref, A., Kelany, M., Abdallah, L., Abdelbakey, F., Ali, D., Ali, D., Ahmed, M., El‐Hafeez, A., Ghosh, P., Alorabi, M. (2021). Clinico-pathological relationship between androgen receptor and tumour infiltrating lymphocytes in triple negative breast cancer. https://doi.org/10.3332/ecancer.2021.1317

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Hagar Elghazawy Joaira Bakkach Thanaa Helal Ahmed Aref Mohamed Kelany L.E. Abdallah Fatma S Abdelbakey Dalia Ali Doaa Z Ali Mai O Ahmed Amer Ali Abd El‐Hafeez Pradipta Ghosh Mohamed Alorabi

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