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Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa

Article scientifique 2023 Anglais

Résumé

Abstract In high-income countries, mosaic chromosomal alterations in peripheral blood leukocytes are associated with an elevated risk of adverse health outcomes, including hematologic malignancies. We investigate mosaic chromosomal alterations in sub-Saharan Africa among 931 children with Burkitt lymphoma, an aggressive lymphoma commonly characterized by immunoglobulin- MYC chromosomal rearrangements, 3822 Burkitt lymphoma-free children, and 674 cancer-free men from Ghana. We find autosomal and X chromosome mosaic chromosomal alterations in 3.4% and 1.7% of Burkitt lymphoma-free children, and 8.4% and 3.7% of children with Burkitt lymphoma ( P -values = 5.7×10 −11 and 3.74×10 −2 , respectively). Autosomal mosaic chromosomal alterations are detected in 14.0% of Ghanaian men and increase with age. Mosaic chromosomal alterations in Burkitt lymphoma cases include gains on chromosomes 1q and 8, the latter spanning MYC , while mosaic chromosomal alterations in Burkitt lymphoma-free children include copy-neutral loss of heterozygosity on chromosomes 10, 14, and 16. Our results highlight mosaic chromosomal alterations in sub-Saharan African populations as a promising area of research.

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Zhou, W., Fischer, A., Ogwang, M., Luo, W., Kerchan, P., Reynolds, S., Tenge, C., Were, P., Kuremu, R., Wekesa, W., Masalu, N., Kawira, E., Kinyera, T., Otim, I., Legason, I., Nabalende, H., Ayers, L., Bhatia, K., Goedert, J., Gouveia, M., Cole, N., Hicks, B., Jones, K., Hummel, M., Schlesner, M., Chagaluka, G., Mutalima, N., Borgstein, E., Liomba, G., Kamiza, S., Mkandawire, N., Mitambo, C., Molyneux, E., Newton, R., Glaser, S., Kretzmer, H., Manning, M., Hutchinson, A., Hsing, A., Tettey, Y., Adjei, A., Chanock, S., Siebert, R., Yeager, M., Prokunina‐Olsson, L., Machiela, M., Mbulaiteye, S. (2023). Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa. https://doi.org/10.1038/s41467-023-43881-0

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Auteur(s)

Weiyin Zhou Anja Fischer Martin D. Ogwang Wen Luo Patrick Kerchan Steven J. Reynolds Constance Tenge Pamela A. Were Robert T. Kuremu Walter N. Wekesa Nestory Masalu Esther Kawira Tobias Kinyera Isaac Otim Ismail D. Legason Hadijah Nabalende Leona W. Ayers Kishor Bhatia James J. Goedert Mateus H. Gouveia Nathan H. Cole Belynda Hicks Kristine M. Jones Michael Hummel Matthias Schlesner George Chagaluka Nora Mutalima Eric Borgstein George N. Liomba Steve Kamiza Nyengo Mkandawire Collins Mitambo Elizabeth Molyneux Robert Newton Selina Glaser Helene Kretzmer Michelle L. Manning Amy Hutchinson Ann W. Hsing Yao Tettey Andrew A. Adjei Stephen J. Chanock Reiner Siebert Meredith Yeager Ludmila Prokunina‐Olsson Mitchell J. Machiela Sam M. Mbulaiteye

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