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Salivary Inflammatory Biomarkers and Glycated Haemoglobin among Patients with type 2 Diabetic Mellitus

Article scientifique 2020 Anglais

Résumé

Abstract Objectives: This study investigated the association of selected salivary inflammatory biomarkers (Interleukin 6 [IL-6], C-reactive protein [CRP], and Tumour necrosis factor α [TNF-α]) to glycated haemoglobin (HbA1C) in type 2 diabetics.Materials and Methods: Seventy-five participants, 39 type 2 diabetics (52%) and 36 (48%) healthy controls were recruited. Saliva and blood samples were collected for each participant. The levels of selected salivary inflammatory biomarkers (IL-6, CRP and TNF-α) were estimated by Enzyme Linked Immunosorbent Assay (ELISA) method and glycated haemogloin (HbA1C) was estimated using the liquid chromatography method. Periodontal status of the participants were determined using the Basic Periodontal Examination (BPE). Results: The mean salivary levels of CRP was significantly higher in diabetics, 0.05±0.04 µg/ml than in controls, 0.02±0.02 µg/ml (p<0.001). Mean TNF-α was also significantly higher in diabetics, 5.39±12.10 pg/ml than in controls, 1.51± 3.66 pg/ml (p=0.036). Mean salivary IL-6 was also higher in diabetics compared with controls (47.20±18.49 versus 41.94±16.88 pg/ml), but the difference was not statistically significant, p=0.204. In the multivariate analysis adjusting for age and periodontal status, only the mean salivary CRP was significantly higher in diabetics, 0.034 higher than controls (95% CI 0.009, 0.059 and p= 0.01). There was a positive correlation between salivary CRP and HbA1C levels, which was moderate with r-value 0.4929 and p-value <0.0001. Conclusions: Salivary inflammatory biomarkers especially CRP are higher in diabetics compared with controls and CRP is positively correlated with serum HbA1C levels. The biomarkers show potentials as non-invasive alternative method to evaluate glycaemic control in diabetes.

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Agho, E., Owotade, F., Kolawole, B., Adedeji, T. (2020). Salivary Inflammatory Biomarkers and Glycated Haemoglobin among Patients with type 2 Diabetic Mellitus. https://doi.org/10.21203/rs.3.rs-115815/v1

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Ekhosuehi Theophilus Agho Foluso Owotade Babatope Kolawole Tewogbade Adeoye Adedeji

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