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Structure of glycine N-acyltransferase clarifies its catalytic mechanism

Article scientifique 2021 Anglais

Résumé

Abstract Glycine N-acyltransferase (GLYAT; EC 2.3.1.13) is a key enzyme in mammalian homeostasis that has been linked to several pathologies in humans, including cancer. Here we report the first crystal structure of a member of the GLYAT family, and a detailed interpretation of its structure and enzymatic mechanism. This work will aid further studies on GLYAT and its involvement in metabolic diseases and cancer.

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Ebrecht, A., Badenhorst, C., Read, R., Opperman, D., Dijk, A. (2021). Structure of glycine N-acyltransferase clarifies its catalytic mechanism. https://doi.org/10.21203/rs.3.rs-857957/v1

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Auteur(s)

Ana C. Ebrecht Christoffel P. S. Badenhorst Randy J. Read Diederik J. Opperman Alberdina van Dijk

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