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Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria

Article scientifique 2018 Anglais

Résumé

Abstract After the successful roll out of MenAfriVac, Nigeria has experienced sequential meningitis outbreaks attributed to meningococcus serogroup C (NmC). Zamfara State in North-western Nigeria recently was at the epicentre of the largest NmC outbreak in the 21 st Century with 7,140 suspected meningitis cases and 553 deaths reported between December 2016 and May 2017. The overall attack rate was 155 per 100,000 population and children 5–14 years accounted for 47% (3,369/7,140) of suspected cases. The case fatality rate (CFR) among children 5–9 years was 10%, double that reported among adults ≥ 30 years (5%). NmC and pneumococcus accounted for 94% (172/184) and 5% (9/184) of the laboratory-confirmed cases, respectively. The sequenced NmC belonged to the ST-10217 clonal complex (CC). All serotyped pneumococci were PCV10 serotypes. The emergence of NmC ST-10217 CC outbreaks threatens the public health gains made by MenAfriVac, which calls for an urgent strategic action against meningitis outbreaks.

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Kwambana-Adams, B., Amaza, R., Okoi, C., Rabiu, M., Worwui, A., Foster-Nyarko, E., Ebruke, B., Sesay, A., Senghore, M., Umar, A., Usman, R., Atiku, A., Garba, A., Buhari, Y., Rabiu, S., Bako, H., Abdullahi, B., Yarima, A., Sikiru, B., Moses, A., Popoola, M., Ekeng, E., Olayinka, A., Mba, N., Kankia, A., Mamadu, I., Okudo, I., Stephen, M., Ronveaux, O., Busuttil, J., Mwenda, J., Abdulaziz, M., Gummi, S., Adedeji, A., Bita, A., Omar, L., Djingarey, M., Alemu, W., D’Alessandro, U., Ihekweazu, C., Antonio, M. (2018). Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria. https://doi.org/10.1038/s41598-018-32475-2

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Auteur(s)

Brenda Kwambana-Adams Rahab Amaza Catherine Okoi Murtala Rabiu Archibald Worwui Ebenezer Foster-Nyarko Bernard E. Ebruke Abdul Karim Sesay Madikay Senghore Abdullahi Shehu Umar Rabi Usman Adamu Atiku Abdullahi Garba Yahaya Buhari Sani Rabiu Husaini U. Bako Bashir Abdullahi Alliyu I. Yarima Badaru Sikiru Aderinola Olaolu Moses Michael Oladotun Popoola Eme Ekeng Adebola Olayinka Nwando Mba Adamu Kankia Ibrahim Mamadu Ifeanyi Okudo Mary Stephen Olivier Ronveaux Jason Busuttil Jason M. Mwenda Mohammed Abdulaziz Sulaiman A. Gummi Adebayo Adedeji André Bita Linda Haj Omar Mamoudou Harouna Djingarey Wondimagegnehu Alemu Umberto D’Alessandro Chikwe Ihekweazu Martín Antonio

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