Review of: "Synthesis of 1, 2-Disubstituted Benzimidazoles at Ambient Temperature Catalyzed by 1-Methylimidazolium Tetraflouroborate ([Hmim] BF_4) and Investigating Their Anti-ovarian Cancer Properties Through Molecular Docking Studies and Calculations"
Résumé
Catalyzed by 1-Methylimidazolium Tetraflouroborate ([Hmim] BF_4) and Investigating Their Anti-ovarian Cancer Properties Through Molecular Docking Studies and Calculations".Authors reported an environmentally benign method for the synthesis of 1, 2-disubstituted benzimidazoles by the reaction of aromatic aldehydes and o-phenylenediamines in the presence of ([Hmim] BF4) under green conditions.The anti-ovarian cancer properties of these compounds were studied only by computational chemistry methods.Here are some suggestions about the manuscript when significant revisions are required.To improve its quality, the following points should be clarified:The title conveniently represents the study, although a spelling mistake has been noticed: tetraflouroborate should be corrected to tetrafluoroborate.Please remove the underscore from the chemical formula of the catalyst.The chemistry part of the study is in general acceptable; however, the docking investigational study is poor, primitive, irrelevant, and should be supported by work conducted on a plausible biological target test as several mechanisms could be involved in activity.It requires major modification to solidify the design as ovarian anticancer agents that should be interpreted into activity.As the major part of the manuscript is based on theoretical studies, this should be backed with biological testing.As these benzimidazole derivatives have been previously synthesized, I wonder if they were tested for such properties.The manuscript requires extensive discussion to reach reasonable conclusions about the anti-ovarian cancer properties.English language should be checked all over the manuscript and corrected.There are language, typographical, spelling, and grammatical mistakes such as "Lee Pinsky", "who ovulate more", "suffers".Some verbs are not correct or not reported in the proper tense, and many sentences should be reconstructed.Repetition has also been observed, as, for example, "Among the heterocyclic compounds, the heterocyclic compounds……."Introduction section should be more concise, avoiding unnecessary information and details, and should be revised
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