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HIV-1 virion lysis following centrifugation improves the sensitivity of the Fourth-Generation HIV Ag/Ab combo assay

Article scientifique 2024 Anglais

Résumé

OBJECTIVE: Fourth-generation HIV Ag/Ab Combo assay is used for HIV screening of blood for transfusion in developing countries, however, the sensitivity of the assay is questionable during the acute phase of HIV infection. Thus, the study aimed to determine the effect of combining centrifugation with HIV-1 virion lysis on the sensitivity of the fourth-generation HIV Ag/Ab combo assay. RESULTS: When the 50 HIV-1 antibody-negative samples were run on the fourth-generation HIV Ag/Ab combo assay, 8 (16%) were positive following centrifugation, 13 (26%) were positive following lysis while 25 (50%) were positive after combining centrifugation with HIV-1 virion lysis.

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Wandera, A., Ssekatawa, K., Kato, C., Kwizera, E., Mujinya, P., Siida, R. (2024). HIV-1 virion lysis following centrifugation improves the sensitivity of the Fourth-Generation HIV Ag/Ab combo assay. https://doi.org/10.1186/s13104-024-06810-y

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Auteur(s)

Allan Wandera Kenneth Ssekatawa Charles Drago Kato Eliah Kwizera Pastori Mujinya Robert Siida

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