In situ green synthesis of Cu-doped ZnO based polymers nanocomposite with studying antimicrobial, antioxidant and anti-inflammatory activities

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Abstract The use of eco-friendly methods for the synthesis of nanoparticles and its nano-composite has become a public demand nowadays to reduce the risks of chemical methods. In the current study, green synthesis of Cu-doped ZnO based polymers nan-ocomposite was performed. Various instrumental analysis including UV–vis, ATR-FTIR spectroscopy, XRD, SEM coupled with energy dispersive X-ray analysis, TEM and Thermal gravimetric were used to characterize nano-composite. Highly antibacterial activity of the synthesized nano-composite was recorded against tested microorganisms with promising efficacy against bacteria namely;Bacillus subtilis,Staphylococcus aureus,Enterococcus faecalis,Proteus vulgaris, Pseudomonas aeruginosa,Escherichia coli,Salmonella typhimuriumand yeast (Candida albicans) but unfortunately not against black fungus (Mucor circinelloides) and filamentous fungiAspergillus flavusandA. niger.Anti-inflammatory of nano-composite represented by hemolysis inhibition was observed at using low concentration (100 µg/mL) with enhancing 23.85% compared with free nano-composite while at high concentrations 500 and1000 µg/mL the anti-inflammatory activity was approximately similar with enhancing 3.91% and 1.99%, respectively. Antioxidant of the nano-composite was better than the antioxidant of free nano-composite at all tested concentrations, moreover the IC50of the nano-composite (91.16 µg/mL) was less than the IC50, (203.65 µg/mL) of the free nano-composite.

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