Accès ouvert

Prognostic and Clinicopathological Implications of NUSAP1, MELK and L1CAM Immunohistochemical Expression in Cervical Cancer

Article scientifique 2021 Anglais

Résumé

Background: Evaluation of cancer cervix prognosis is highly needed for novel targeted therapy and improved outcomes. Nucleolar and spindle associated protein 1 (NUSAP1) is a novel biomarker that has roles in spindle formation and mitotic progression. Maternal embryonic leucine zipper kinase (MELK) is involved in cell cycle control and carcinogenesis. The L1 cell adhesion molecule (L1-CAM) plays an essential role in cell migration. This study aimed to investigate NUSAP1, MELK, and L1CAM immunohistochemical expression in cancer cervix tissues and detect their prognostic roles. Method: In this prospective cohort study, we evaluated NUSAP1, MELK, and L1CAM expressions of sections from 62 cervical carcinoma cases using immunohistochemistry. Results: NUSAP1, MELK, and L1CAM expression correlated with tumor high grade, advanced FIGO stage, poor survival rates, and higher recurrence rate after successful therapy (p <0.001). Conclusion: Expression of NUSAP1, MELK, and L1CAM in cancer cervix was associated with poor prognosis.

Citer ce document

Elfeky, M., Harb, O., Shafaay, B., Obaya, A., Awd, A., Alkilany, M., Gertallah, L. (2021). Prognostic and Clinicopathological Implications of NUSAP1, MELK and L1CAM Immunohistochemical Expression in Cervical Cancer. https://doi.org/10.30476/mejc.2020.82884.1115

Accès au document

Voir sur le dépôt source

Ce document est hébergé sur son dépôt institutionnel d'origine.

Auteur(s)

Mariem A. Elfeky Ola A. Harb Basant Sh El Shafaay Ahmed Obaya Amr A. Awd Mohamed Alkilany Loay M. Gertallah

Statistiques

Consultations : 1

Téléchargements : 0