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First wave COVID-19 pandemic in Senegal: Epidemiological and clinical characteristics

Article scientifique 2022 Anglais

Résumé

BACKGROUND: The novel coronavirus disease 2019 (COVID-19) pandemic has spread from China to the rest of the world. Africa seems less impacted with lower number of cases and deaths than other continents. Senegal recorded its first case on March 2, 2020. We present here data collected from March 2 to October 31, 2020 in Senegal. METHODS: Socio-demographic, epidemiological, clinical and virological information were collected on suspected cases. To determine factors associated with diagnosed infection, symptomatic disease and death, multivariable binary logistic regression and log binomial models were used. Epidemiological parameters such as the reproduction number and growth rate were estimated. RESULTS: 67,608 suspected cases were tested by the IPD laboratories (13,031 positive and 54,577 negative). All age categories were associated with SARS-CoV-2 infection, but also patients having diabetes or hypertension or other cardiovascular diseases. With diagnosed infection, patients over 65 years and those with hypertension and cardiovascular disease and diabetes were highly associated with death. Patients with co-morbidities were associated with symptomatic disease, but only the under 15 years were not associated with. Among infected, 27.67% were asymptomatic (40.9% when contacts were systematically tested; 12.11% when only symptomatic or high-risk contacts were tested). Less than 15 years-old were mostly asymptomatic (63.2%). Dakar accounted for 81.4% of confirmed cases. The estimated mean serial interval was 5.57 (± 5.14) days. The average reproduction number was estimated at 1.161 (95%CI: 1.159-1.162), the growth rate was 0.031 (95%CI: 0.028-0.034) per day. CONCLUSIONS: Our findings indicated that factors associated with symptomatic COVID-19 and death are advanced age (over 65 years-old) and comorbidities such as diabetes and hypertension and cardiovascular disease.

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Diarra, M., Barry, A., Dia, N., Diop, M., Sonko, I., Sagne, S., Sarr, F., Talla, C., Tall, A., Faye, J., Diop, B., Diagne, C., Gaye, A., Diallo, A., Mbaye, R., Cissé, M., Taïeb, F., Faye, O., Lakhe, N., Samba, B., Diallo, K., Fall, N., Badiane, A., Fortes, L., Diop, M., Thioub, D., Ly, A., Faye, O., Seydi, M., Bousso, A., Sall, A., Loucoubar, C. (2022). First wave COVID-19 pandemic in Senegal: Epidemiological and clinical characteristics. https://doi.org/10.1371/journal.pone.0274783

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Auteur(s)

Maryam Diarra Aliou Barry Ndongo Dia Mamadou Diop Ibrahima Sonko Samba Sagne Fatoumata Diène Sarr Cheikh Talla Adama Tall Joseph Faye Boly Diop Cheikh Tidiane Diagne Aboubacry Gaye Amadou Diallo Rose Mbaye Mamadou Cissé Fabien Taïeb Oumar Faye Ndèye Aïssatou Lakhe Ba Papa Samba Khardiata Diallo Ndèye Maguette Fall Aboubakar Sadikh Badiane Louise Fortes Moustapha Diop Daouda Thioub Alioune Badara Ly Ousmane Faye Moussa Seydi Abdoulaye Bousso Amadou A. Sall Cheikh Loucoubar

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